期刊
PRION
卷 1, 期 1, 页码 3-8出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/pri.1.1.3969
关键词
protein aggregation; simulations; amyloid fibril; oligomers; coarse-grained model; inhibitors
资金
- NSERC
- FQRNT
- Canada Research Chair Program
- CNRS
- University Paris 7
- 6<SUP>th</SUP> European PCRD
- Alzheimer Society of Canada
There is strong evidence that the oligomers of key proteins, formed during the early steps of aggregation, could be the primary toxic species associated with human neuro-degenerative diseases, such as Alzheimer's and prion diseases. Here, we review recent progress in the development of computational approaches in order to understand the structures, dynamics and free energy surfaces of oligomers. We also discuss possible research directions for the coming years.
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