期刊
NANOTOXICOLOGY
卷 1, 期 3, 页码 235-242出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17435390701763108
关键词
Nanogold; nanoparticles; nanomaterials; inhalation; lung; kidney; smooth muscle; phosphatidylserine; microarray; lipidomics
资金
- Office of Life Sciences
- NUS Environmental Research Institute
- NUS Nanoscience and Nanotechnology Initiative
This study was carried out to test the hypothesis that nanogold particles can accumulate in the olfactory bulb, and translocate from the lung to other organs after inhalation exposure. Gold nanoparticles were aerosolized and introduced through an exposure chamber. The number concentration of airborne nano-sized particles was 2 x 10(6) #NSPs/cm(3) with > 75% of particulates between 30 and 110 nm. Exposure for 5 days resulted in significant increase of Au in the lung and olfactory bulb as detected by ICP-MS, but after 15 days, significant accumulation of gold was detected in the lung, esophagus, tongue, kidney, aorta, spleen, septum, heart and blood. Microarray analysis showed downregulation of many genes related to muscle in the nanogold-exposed lung. Lipidomic analysis of the lung showed a specific decrease in phosphatidylserine 36: 1 species. We conclude that nanogold is able to translocate from the lung to other organs with time, and causes significant effects in exposed tissues.
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