期刊
CANCER CAUSES & CONTROL
卷 22, 期 3, 页码 319-340出版社
SPRINGER
DOI: 10.1007/s10552-010-9706-3
关键词
Vitamin D; Prostatic neoplasms; Review; Meta-analysis; Epidemiology
资金
- Cancer Research UK [C31211/A10095]
- World Cancer Research Fund [2006/15]
- Medical Research Council [G0801462, G0501864, G0900871] Funding Source: researchfish
- MRC [G0501864, G0900871] Funding Source: UKRI
Objective We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH) D), and 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D) concentrations) with prostate cancer. Methods We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response random-effects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I-2 statistic quantified between-study variation due to heterogeneity. Results Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I-2 = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I-2 = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I-2 = 49%). The OR per 10 ng/mL increase in 25(OH) D was 1.04 (14 studies; 0.99, 1.10; I-2 = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I-2 = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH) 2D was 1.00 (7 studies; 0.87, 1.14; I-2 = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I-2 = 0%) for aggressive prostate cancer. Conclusion Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据