期刊
CANCER CAUSES & CONTROL
卷 21, 期 12, 页码 2269-2279出版社
SPRINGER
DOI: 10.1007/s10552-010-9652-0
关键词
Adenocarcinoma; Barrett's esophagus; Epidemiology; Ferritin; Iron
资金
- Health and Social Care Research & Development Office
- National Cancer Institute
- Health and Social Care Research & Development Office (Belfast, Northern Ireland)
- National Cancer Institute (Bethesda, MD, USA)
- ESRC [ES/G007438/1] Funding Source: UKRI
- Economic and Social Research Council [ES/G007438/1] Funding Source: researchfish
- Medical Research Council [MC_CF023241] Funding Source: researchfish
- Public Health Agency [CDV/3678/07] Funding Source: researchfish
Objective To investigate the association between iron intake and iron status with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Methods A total of 220 BE patients, 224 EAC patients, and 256 frequency-matched controls completed a lifestyle and food frequency questionnaire and provided serum and toenail samples between 2002 and 2005. Using multiple logistic regression, odds ratios (OR) and 95% confidence intervals (95% CI) were calculated within quartiles of intake/status. Results Comparing the fourth to the first quartile, ferritin (OR 0.47; 95% CI: 0.23, 0.97) and transferrin saturation (OR 0.41; 95% CI: 0.20, 0.82) were negatively associated with BE; while total iron binding capacity was positively associated per 50 mu g/dl increment (OR 1.47; 95% CI: 1.12, 1.92). Comparing the fourth to the first quartile, iron intake (OR 0.50; 95% CI: 0.25, 0.98), non-heme iron intake per 10 mg/day increment (OR 0.29; 95% CI: 0.08, 0.99), and toenail iron (OR 0.40; 95% CI: 0.17, 0.93) were negatively associated with EAC; while heme iron intake was positively associated (OR 3.11 95% CI: 1.46, 6.61). Principal conclusion In contrast to the hypothesis that increased iron intakes and higher iron stores are a risk factor for BE and EAC, this study suggests that higher iron intakes and stores may have a protective association with BE and EAC, with the exception of what was found for heme iron intake.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据