Circulating fatty acids and prostate cancer risk in a nested case-control study: the Multiethnic Cohort

Objective Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting. Methods We examined the association between erythrocyte membrane fatty acid composition and prostate cancer risk in a nested case-control study within a multiethnic cohort of African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites. Analyses included 376 cases and 729 matched controls. Conditional logistic regression was used to estimate the odds ratios and 95% confidence intervals with adjustment for multiple covariates. Results No significant association was found for saturated, mono-and polyunsaturated fatty acid, or for specific n-3 and n-6 fatty acids, even when the analysis was limited to advanced or high grade prostate cancer. In ethnic specific analyses, there was a positive association with palmitic acid in Japanese Americans that was significantly different from the null results in other groups. There was also an increased risk with n-3 fatty acids and the ratio of n-3/n-6 fatty acids in Whites. Conclusion Although there was a suggestion of ethnic specific associations with some fatty acids, our overall findings do not support a role for fatty acids in prostate carcinogenesis.