期刊
BLOOD
卷 109, 期 7, 页码 3050-3059出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-07-034330
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资金
- DIVISION OF CANCER CONTROL &POPULATION SCIENCE [N01PC067010, N01PC065064, N01PC067008] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [Z01SC010083] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01 PC067009, N01 PC067008, N01 PC065064, N01 PC067010] Funding Source: Medline
We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (Cis) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR=0.22; 95% Cl = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% Cl = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% Cl = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% Cl = 0.44-0.91), MTHFR Ex8-62A> C CC (OR = 0.13; 95% Cl = 0.04-0.39), and MTRR Ex5+136T>CTT (OR = 0.67; 95%Cl = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis.
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