期刊
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
卷 29, 期 10, 页码 403-411出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/cbr.2014.1642
关键词
oncolytic adenovirus; hepatocellular carcinoma; Mn-SOD
类别
资金
- National Nature Science Foundation of China [81272687]
- Zhejiang Provincial Natural Science Foundation of China [LZ13H160004]
- China 863 Program [2012AA020806]
- 521 talent project of ZSTU
- Zhejiang province public welfare technology applied research projects [2014C33275]
Although the treatment methods for hepatocellular carcinoma (HCC) have made a great progress on patient survival rate and life quality, the HCC recurrence still is very high. To explore the novel effective anticancer strategies for HCC, the Cancer Targeting Gene-Viro-Therapy (CTGVT) strategy was applied through oncolytic virus-delivery antitumor gene. In this article, the dual-regulated oncolytic adenovirus Ad-AFP-E1A-E1B((Delta 55kDa))-Mn-SOD (briefly named AD55-Mn-SOD) was constructed using a liver cancer-specific alpha-fetoprotein (AFP) promoter to control replication-essential E1A gene and deliver the novel tumor suppression gene Manganese superoxide dismutase (Mn-SOD). The results indicated that the constructed AD55-Mn-SOD exerted tumor-specific features, and induced dramatic cytotoxicity in HCC cells in vitro and suppress the HCC xenografted growth in nude mice. Moreover, the anticancer mechanism of AD55-Mn-SOD is due to the activation of caspase apoptotic pathway. These data suggested that AD55-Mn-SOD could become a potential anticancer agent for liver cancer.
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