期刊
CANCER BIOMARKERS
卷 10, 期 6, 页码 251-258出版社
IOS PRESS
DOI: 10.3233/CBM-2012-0256
关键词
Pancreas; adenocarcinoma; prion; prp; prognosis; immunohistochemistry; biomarker
类别
资金
- Pathology Association of University Hospital of Cleveland Research Grant
- Department of Pathology of Case Western Reserve University
- SEER (Iowa) [NO1-PC-35143]
- SEER (Hawaii) [NO1-PC-35137]
- SEER (Los Angeles) [NO1-PC-35139]
Pancreatic ductal adenocarcinoma (PDAC) is an important cause of cancer death with no clear prognostic biomarker. Expression of prion (PrP) has been reported to be a marker of poor prognosis in a series of Caucasian PDAC cases. We determined the prognostic value of PrP in a racially and geographically diverse population-based series of PDAC cases. PrP expression was examined in 142 PDAC cases from three cancer registries. Cases included 71 Caucasian, 54 Asian/Pacific Islanders and 17 Blacks diagnosed from 1983-2000, and followed through 2008. Hazard ratios (HR) and 95% confidence intervals (CIs) for the association of PrP expression with survival were computed after adjustment for case attributes. The risk of death was about four times higher (HR = 3.8; 95% CI: 2.2, 6.5) among 108 PDAC cases with PrP+ tumors (median survival 5 months) compared to the 34 cases with PrP- tumors (median survival 20 months). Of 51 cases with resected, localized PDAC median survival was 74 months for 17 cases with PrP- tumors versus 14 months for 34 cases with PrP+ tumors (HR = 6.7; 95% CI: 2.6, 17.4). All 6 surviving cases had PrP- negative tumors (median survival, > 10 years). PrP may have potential as a prognostic biomarker in PDAC patient management.
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