期刊
BLOOD
卷 109, 期 1, 页码 339-342出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-03-009472
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL076309, R01HL079441] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL076309, HL079441, R01 HL079441, R01 HL076309, R01 HL079441-02, R01 HL076309-05] Funding Source: Medline
Recently, the JAK2(V617F) mutation was found in patients with myeloproliferative disorders (MPDs), including most with polycythemia vera (PV). The mutant JAK2 has increased kinase activity, and it was shown to be pathogenic in mouse models. Herein, we analyzed blood samples randomly collected from a clinical laboratory. Surprisingly, as many as 37 samples from a total of 3935 were found positive for the JAK2 mutation. However, only one of these samples had blood test results indicative for probable PV, but several had nonhematologic diseases. On average, samples with the mutation had normal red cell counts but significantly higher white blood cell and platelet counts, although most were within the normal range. The data suggest that the JAK2V617F mutation is apparently much more common than MPDs. Its occurrence may be a prelude to full blood cell abnormalities and other diseases, but it cannot by itself diagnose MPDs. (c) 2007 by The American Society of Hematology
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