期刊
CANCER BIOLOGY & THERAPY
卷 15, 期 4, 页码 473-478出版社
LANDES BIOSCIENCE
DOI: 10.4161/cbt.27824
关键词
arsenic trioxide; myeloid leukemia; apoptosis; autophagy
类别
资金
- National Institutes of Health [CA121192, CA155566, CA77816, CA174205]
- Department of Veterans Affairs [I01CX000916]
- NIH [T32CA070085]
Efforts to enhance the antileukemic properties of arsenic trioxide are clinically relevant and may lead to the development of new therapeutic approaches for the management of certain hematological malignancies. We provide evidence that concomitant treatment of acute myeloid leukemia (AML) cells or chronic myeloid leukemia (CML) cells with resveratrol potentiates arsenic trioxide-dependent induction of apoptosis. Importantly, clonogenic assays in methylcellulose demonstrate potent suppressive effects of the combination of these agents on primitive leukemic progenitors derived from patients with AML or CML. Taken together, these findings suggest that combinations of arsenic trioxide with resveratrol may provide an approach for targeting of early leukemic precursors and, possibly, leukemia initiating stem cells.
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