4.5 Review

Autophagy as a therapeutic target in cancer

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Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells

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Autophagy protects LNCaP cells under androgen deprivation conditions

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The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

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Hypothalamic CaMKK2 contributes to the regulation of energy balance

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Chemopreventive effects of natural dietary compounds on cancer development

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Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: The contribution of autophagic cell death

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Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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Induction of autophagy during extracellular matrix detachment promotes cell survival

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JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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NATURE (2008)

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Autophagy fights disease through cellular self-digestion

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Regulation of autophagy by cytoplasmic p53

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NATURE CELL BIOLOGY (2008)

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Autophagic cell death: the story of a misnomer

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Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle

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NEUROMUSCULAR DISORDERS (2008)

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PTEN: a new guardian of the genome

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How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

Wei-Lien Yen et al.

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Review Cell Biology

Autophagy, amyloidogenesis and Alzheimer disease

Ralph A. Nixon

JOURNAL OF CELL SCIENCE (2007)

Article Oncology

Role of autophagy in cancer

Robin Mathew et al.

NATURE REVIEWS CANCER (2007)

Article Cell Biology

Differential interactions between Beclin 1 and bcl-2 family members

Shlomit Erlich et al.

AUTOPHAGY (2007)

Article Cell Biology

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

Yoshinori Takahashi et al.

NATURE CELL BIOLOGY (2007)

Article Cell Biology

Modulating autophagy for therapeutic benefit

Jennifer S. Carew et al.

AUTOPHAGY (2007)

Article Multidisciplinary Sciences

Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a mutation pattern

Christian Hafner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cell Biology

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

Vassiliki Karantza-Wadsworth et al.

GENES & DEVELOPMENT (2007)

Article Cell Biology

Autophagy suppresses tumor progression by limiting chromosomal instability

Robin Mathew et al.

GENES & DEVELOPMENT (2007)

Article Cell Biology

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

Emilie Vander Haar et al.

NATURE CELL BIOLOGY (2007)

Article Cell Biology

Autophagy regulates ageing in C-elegans

Enter S. Hars et al.

AUTOPHAGY (2007)

Article Cell Biology

Metabolic catastrophe as a means to cancer cell death

Shengkan Jin et al.

JOURNAL OF CELL SCIENCE (2007)

Article Biochemistry & Molecular Biology

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2

Maria Hoyer-Hansen et al.

MOLECULAR CELL (2007)

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PTEN: Its deregulation and tumorigenesis

Tomohiko Maehama

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)

Article Biochemistry & Molecular Biology

Autophagy delays apoptotic death in breast cancer cells following DNA damage

M. J. Abedin et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Autophagy is activated for cell survival after endoplasmic reticulum stress

Maiko Ogata et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

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Endoplasmic reticulum stress triggers autophagy

Tomohiro Yorimitsu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

MTOR, translation initiation and cancer

Y. Mamane et al.

ONCOGENE (2006)

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Autophagy in cancer: Good, bad, or both?

Melanie M. Hippert et al.

CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

mTOR and cancer therapy

J. B. Easton et al.

ONCOGENE (2006)

Article Biochemistry & Molecular Biology

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

Diane Crighton et al.

Article Cell Biology

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

Chengyu Liang et al.

NATURE CELL BIOLOGY (2006)

Review Cell Biology

Autophagy and cancer therapy

Yasuko Kondo et al.

AUTOPHAGY (2006)

Article Multidisciplinary Sciences

The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

JJ Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Autophagy and signaling: their role in cell survival and cell death

P Codogno et al.

CELL DEATH AND DIFFERENTIATION (2005)

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Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death

M Hoyer-Hansen et al.

CELL DEATH AND DIFFERENTIATION (2005)

Review Cell Biology

Autophagy and aging -: The importance of maintaining clean cells

Ana Maria Cuervo et al.

AUTOPHAGY (2005)

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

S Pattingre et al.

Review Biochemistry & Molecular Biology

An expanding role for mTOR in cancer

DA Guertin et al.

TRENDS IN MOLECULAR MEDICINE (2005)

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Metformin and reduced risk of cancer in diabetic patients

JMM Evans et al.

BMJ-BRITISH MEDICAL JOURNAL (2005)

Review Cell Biology

Autophagy in metazoans: Cell survival in the land of plenty

JJ Lum et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Inhibition of macroautophagy triggers apoptosis

P Boya et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Review Oncology

The role of autophagy in cancer development and response to therapy

Y Kondo et al.

NATURE REVIEWS CANCER (2005)

Article Biochemistry & Molecular Biology

Dictyostelium macroautophagy mutants vary in the severity of their developmental defects

GP Otto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

T Kanzawa et al.

CELL DEATH AND DIFFERENTIATION (2004)

Article Multidisciplinary Sciences

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

RJ Shaw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Oncology

Resveratrol-induced autophagocytosis in ovarian cancer cells

AW Opipari et al.

CANCER RESEARCH (2004)

Review Multidisciplinary Sciences

Autophagy in health and disease: A double-edged sword

T Shintani et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

ZY Yue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

TSC2 mediates cellular energy response to control cell growth and survival

K Inoki et al.

Article Biochemistry & Molecular Biology

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

A Woods et al.

CURRENT BIOLOGY (2003)

Review Oncology

The phosphatidylinositol 3-kinase-AKT pathway in human cancer

I Vivanco et al.

NATURE REVIEWS CANCER (2002)

Article Biochemistry & Molecular Biology

TP53: a key gene in human cancer

DP Guimaraes et al.

BIOCHIMIE (2002)

Article Multidisciplinary Sciences

Longevity - Extending the lifespan of long-lived mice

A Bartke et al.

NATURE (2001)

Review Multidisciplinary Sciences

Oncogenic kinase signalling

P Blume-Jensen et al.

NATURE (2001)

Review Oncology

PTEN: Life as a tumor suppressor

L Simpson et al.

EXPERIMENTAL CELL RESEARCH (2001)