期刊
CANCER BIOLOGY & THERAPY
卷 12, 期 6, 页码 477-483出版社
LANDES BIOSCIENCE
DOI: 10.4161/cbt.12.6.16300
关键词
miR-34a; glioblastoma multiforme; proliferation; apoptosis; notch1; U373MG; SHG44; target gene
类别
资金
- National Natural Science Foundation of China [30973255H1205]
Aberrant expression of microRNAs (miRNAs) has been implicated in cancer initiation and progression. In this study, we found that microRNA-34a (miR-34a) is significantly downregulated in glioblastoma multiforme (GBM) specimens compared with normal brain tissues. Growth curve and colony formation assays revealed that miR-34a suppresses proliferation of U373MG and SHG44 glioblastoma cells. Overexpression of miR-34a could induce apoptosis of glioblastoma cells. Also, we identified notch1 as a direct target gene of miR-34a. Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo. Collectively, our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据