期刊
CANCER BIOLOGY & THERAPY
卷 11, 期 9, 页码 812-815出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.11.9.15178
关键词
mesenchymal stem cells; bone marrow; microenvironment; cancer-initiating cells; cancer stem cells
类别
资金
- State of Texas
- National Cancer Institute [R01, CA138239-02]
Purpose: The bone marrow microenvironment is considered a critical component in the dissemination and fate of cancer cells in the metastatic process. We explored the possible correlation between bone marrow mesenchymal stem cells (BM-MSC) and disseminated breast cancer-initiating cells (BCIC) in primary breast cancer patients. Results: The percentages of BCIC (Aldefluor(+)CD326(+)CD44(+)CD24(-)) correlated with the percentages of BM-MSC, either CD45(-)GD2(+)CD200(+)CD271(+) (Kedall's tau = 0.684, p = 0.004) or CD45(-)GD2(+)CD271(+) in the bone marrow (Kedall's tau = 0.464, p = 0.042). Experimental Design: Bone marrow mononuclear cells (BM-MNC) were collected at the time of primary surgery in 12 breast cancer patients. BM-MNC was immunophenotyped and BCIC was defined as epithelial cells (CD326(+)CD45(-)) with a stem-like phenotype (CD44(+)CD24(low/-), ALDH activity). BM-MSC was defined as CD34(-)CD45(-) cells that co-expressed GD2, CD271 and/or CD200 within CD326-depleted BM-MNC. Conclusions: There was a positive correlation between mesenchymal stem cells expressing GD2 and CD271 and breast cancer-initiating cells in BM of patients with primary breast cancer.
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