期刊
CANCER BIOLOGY & THERAPY
卷 10, 期 6, 页码 582-587出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.10.6.12537
关键词
pancreatic cancer; cancer drivers; CHASM; missense mutations; somatic mutations
类别
资金
- DoD
- Air Force Office of Scientific Research
- National Defense Science and Engineering Graduate (NDSEG) [32 CFR 168a]
- National Science Foundation [DBI 0845275]
- NIH NCI [R21 CA135866]
Over 20,000 genes were recently sequenced in a series of 24 pancreatic cancers. We applied CHASM (Cancer-specific High-throughput Annotation of Somatic Mutations) to 963 of the missense somatic missense mutations discovered in these 24 cancers. CHASM identified putative driver mutations (false discovery rate <= 0.3) in three known pancreatic cancer driver genes (P53, SMAD4, CDKN2A). An additional 15 genes with putative driver mutations include genes coding for kinases (PIK3CG, DGKA, STK33, TTK and PRKCG), for cell cycle related proteins (NEK8), and for proteins involved in cell adhesion (CMAS, PCDHB2). These and other mutations identified by CHA SM point to potential driver genes in pancreatic cancer that should be prioritized for additional follow-up.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据