期刊
CANCER BIOLOGY & THERAPY
卷 9, 期 9, 页码 655-667出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.9.9.11511
关键词
Ewing sarcoma; EWS-ETS; pediatric; molecular targets; signaling pathways; mouse models; novel therapies
类别
资金
- Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation [PI052524, RD06/0020/0059, CD06/00001]
- Fundacion Memoria D. Samuel Solorzano Barruso
Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
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