期刊
CANCER BIOLOGY & THERAPY
卷 8, 期 10, 页码 917-922出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.8.10.8141
关键词
TNF-related apoptosis inducing ligand (TRAIL); death receptor; endocytosis; apoptosis; caspases; cleavage; breast cancer cells
类别
资金
- FDA Critical Path Fund
TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent that selectively induces apoptosis in cancer cells over normal cells. Here, we show that TRAIL undergoes rapid endocytosis with its death receptors DR4, and likely DR5, in MDA-MB-231 human breast cancer cells. The internalized DR4, but not DR5, is cleaved in a caspase-dependent manner. Blockade of receptor internalization does not prevent caspase activation, but rather enhances apoptosis after TRAIL treatment. TRAIL-induced receptor endocytosis appears to undermine its ability in inducing apoptosis.
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