期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 1, 页码 55-63出版社
WILEY
DOI: 10.1359/JBMR.060915
关键词
osteoprotegerin; alendronate; PTH; bone turnover; skeletal coupling
We examined the effects of 60 days of co-treatment of PTH with either OPG or alendronate in oophorectomized mice. Compared with PTH alone, co-treatment of PTH with either of these two mechanistically distinct anti-catabolics improved bone volume, mechanical strength, and appendicular and axial mineralization and prolonged the beneficial effect of PTH on BMD.
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