期刊
CANCER BIOLOGY & THERAPY
卷 7, 期 2, 页码 157-162出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.7.2.5270
关键词
gastric cancer; polymorphisms; cytokines; gene association; Helicobacter pylori
类别
资金
- NCI NIH HHS [P01CA028842] Funding Source: Medline
More than 20 years after the identification of Helicobacter pylori as a human pathogen, gastric cancer continues to be a leading cause of cancer deaths worldwide. Genetic association studies have the potential for helping to identify those at greatest risk for developing gastric cancer subsequent to infection by H. pylori. IL1B promoter polymorphisms have been supported by several meta-analyses as being associated with gastric cancer risk. In this review, we discuss challenges in experimental design of gene association studies in gastric cancer, with attention to gene-environment interactions that may lead to inconsistency in findings across populations.
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