期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 1, 页码 72-82出版社
WILEY-BLACKWELL
DOI: 10.1359/JBMR.060911
关键词
growth hormone receptor gene disrupted or knockout mice; puberty; orchidectomy; androgens; growth hormone; insulin-like growth factor I; trabecular bone; periosteal bone; muscle mass
资金
- NIA NIH HHS [R01 AG19899-02] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG019899] Funding Source: NIH RePORTER
The interaction between androgens and GH/IGF-I was studied in male GHR gene disrupted or GHRKO and WT mice during puberty. Androgens stimulate trabecular and cortical bone modeling and increase muscle mass even in the absence of a functional GHR. GHR activation seems to be the main determinant of radial bone expansion, although GH and androgens are both necessary for optimal stimulation of periosteal growth during puberty.
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