Effect of enzyme replacement therapy with imiglucerase on BMD in type 1 Gaucher disease

The effect of ERT with imiglucerase on BMD in type I GD was studied using BMD data from the International Collaborative Gaucher Group Gaucher Registry. Data were analyzed for 160 untreated patients and 342 ERT-treated patients. Imiglucerase significantly improves BMD in patients with GD, with 8 years of ERT leading to normal BMD..