期刊
CANCER AND METASTASIS REVIEWS
卷 33, 期 2-3, 页码 441-468出版社
SPRINGER
DOI: 10.1007/s10555-013-9483-z
关键词
Epithelial plasticity; Prostate cancer; Metastasis; Epithelial-mesenchymal transition; Dissemination; Stem cell
类别
资金
- NIGMS [R01 GM63090]
- National Cancer Institute [R01 CA127727]
- Robert B. Goergen Prostate Cancer Foundation Young Investigator Award
- Department of Defense Physician Research Training Award [W81XWH-10-1-0483]
Nearly 30,000 men die annually in the USA of prostate cancer, nearly uniformly from metastatic dissemination. Despite recent advances in hormonal, immunologic, bone-targeted, and cytotoxic chemotherapies, treatment resistance and further dissemination are inevitable in men with metastatic disease. Emerging data suggests that the phenomenon of epithelial plasticity, encompassing both reversible mesenchymal transitions and acquisition of stemness traits, may underlie this lethal biology of dissemination and treatment resistance. Understanding the molecular underpinnings of this cellular plasticity from preclinical models of prostate cancer and from biomarker studies of human metastatic prostate cancer has provided clues to novel therapeutic approaches that may delay or prevent metastatic disease and lethality over time. This review will discuss the preclinical and clinical evidence for epithelial plasticity in this rapidly changing field and relate this to clinical phenotype and resistance in prostate cancer while suggesting novel therapeutic approaches.
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