期刊
CANCER AND METASTASIS REVIEWS
卷 32, 期 3-4, 页码 603-621出版社
SPRINGER
DOI: 10.1007/s10555-013-9440-x
关键词
Central nervous system; Cancer metastasis; Host macroenvironment; Peripheral nervous system; Tumor microenvironment
类别
资金
- National Basic Research Program of China (973 program) [2010CB911904]
- National Natural Science Foundation of China [30901766, 30972690, 30800582]
- Beijing Natural Science Foundation [7122124, 7132163]
Central and sympathetic nervous systems govern functional activities of many organs. Solid tumors like organs are also innervated by sympathetic nerve fibers. Neurotransmitters released from sympathetic nerve fibers can modulate biological behaviors of tumor cells. Multiple physiologic processes of tumor development may be dominated by central and sympathetic nervous systems as well. Recent studies suggest that dysfunction of central and sympathetic nervous systems and disorder of the hormone network induced by psychological stress may influence malignant progression of cancer by inhibiting the functions of immune system, regulating metabolic reprogramming of tumor cells, and inducing interactions between tumor and stromal cells. Over-release of inflammatory cytokines by tumors may aggravate emotional disorder, triggering the vicious cycles in tumor microenvironment and host macroenvironment. It is reasonable to hypothesize that cancer progression may be controlled by central and sympathetic nervous systems. In this review, we will focus on the recent information about the impacts of central and sympathetic nervous systems on tumor invasion and metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据