期刊
CANCER AND METASTASIS REVIEWS
卷 30, 期 1, 页码 61-69出版社
SPRINGER
DOI: 10.1007/s10555-011-9273-4
关键词
Apoptosis; ATP; Calreticulin; HMGB1; Necrosis; Spatiotemporal codes
类别
资金
- Ligue Nationale contre le Cancer (Equipes labellisee)
- Agence Nationale pour la Recherche (ANR)
- European Commission (Apo-Sys, ChemoRes, ApopTrain)
- Fondation pour la Recherche Medicale (FRM)
- Institut National du Cancer (INCa)
- Canceropole Ile-de-France
- Ligue Nationale contre le Cancer
- AICR
The success of some chemo- and radiotherapeutic regimens relies on the induction of immunogenic tumor cell death and on the induction of an anticancer immune response. Cells succumbing to immunogenic cell death undergo specific changes in their surface characteristics and release proimmunogenic factors according to a defined spatiotemporal pattern. This stimulates antigen presenting cells such as dendritic cells to efficiently take up tumor antigens, process them, and cross-prime cytotoxic T lymphocytes, thus eliciting a tumor-specific cognate immune response. Such a response can also target therapy-resistant tumor (stem) cells, thereby leading, at least in some instances, to tumor eradication. In this review, we shed some light on the molecular identity of the factors that are required for cell death to be perceived as immunogenic. We discuss the intriguing observations that the most abundant endoplasmic reticulum protein, calreticulin, the most abundant intracellular metabolite, ATP, and the most abundant nonhistone chromatin-binding protein, HMGB 1, can determine whether cell death is immunogenic as they appear on the surface or in the microenvironment of dying cells.
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