期刊
CANCER AND METASTASIS REVIEWS
卷 28, 期 1-2, 页码 77-83出版社
SPRINGER
DOI: 10.1007/s10555-008-9167-2
关键词
DLC-1; Cell migration; Cell invasion
类别
资金
- NIGMS NIH HHS [R01 GM080981-02, R01 GM080981] Funding Source: Medline
DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a GTPase activating protein (GAP) for members of the Rho family of GTPases, particularly Rho A-C and Cdc 42. Since these GTPases are critically involved in regulation of the cytoskeleton and cell migration, it seems clear that DLC-1 will also influence these processes. In this review we examine basic aspects of the actin cyoskeleton and how it relates to cell motility. We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据