期刊
CANCER AND METASTASIS REVIEWS
卷 27, 期 2, 页码 215-230出版社
SPRINGER
DOI: 10.1007/s10555-008-9115-1
关键词
PTP1B; TC-PTP; protein tyrosine phosphatase; cancer; inflammation
类别
PTP1B and T cell PTP (TC-PTP) are protein tyrosine phosphatases (PTPs) that share high sequence and structural homology yet play distinct physiological roles. While PTP1B plays a central role in metabolism and is an attractive drug target for obesity and type 2 diabetes, TC-PTP is necessary for the control of inflammation. In this review, we will discuss the growing evidence for the involvement of PTP1B in cancer, while proposing a role for TC-PTP in inflammation-induced tumorigenesis. Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models.
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