期刊
CANCER AND METASTASIS REVIEWS
卷 27, 期 4, 页码 679-690出版社
SPRINGER
DOI: 10.1007/s10555-008-9152-9
关键词
near infrared; MMP; in vivo imaging; MRI; PET; SPECT
类别
资金
- NIH [CA 60867, CA 84360]
- Vanderbilt-Ingram Cancer Center [P30CA068485]
- RLS
- NSF [0333392]
- Direct For Education and Human Resources
- Division Of Graduate Education [0333392] Funding Source: National Science Foundation
Early detection of both primary tumors and metastatic disease remains a major challenge in the diagnosis and staging of cancer. The recognition of the role of MMPs in both the growth and metastasis of tumors has guided the development not only of therapeutic strategies utilizing synthetic, small-molecule MMP inhibitors (MMPIs), but has also catalyzed methods to detect and image tumors in vivo by means of tumor-associated proteolytic activity. These imaging approaches target MMPs involved in cancer progression via contrast agents linked to MMPIs or to MMP selective and specific substrates with sensitivity enhanced by amplification during enzymatic processing. This review draws attention to a variety of strategies utilized to image MMP activity in vivo.
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