期刊
FEBS JOURNAL
卷 274, 期 11, 页码 2878-2886出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1742-4658.2007.05822.x
关键词
cell-cell communication; metabolic cycle; microarray; ribogenesis cycle; systems biology
The ergodic hypothesis, which assumes the independence of each cell of the ensemble from all the others, is a necessary prerequisite to attach single cell based explanations to the grand averages taken from population data. This was the prevailing view about the interpretation of cellular biology experiments that typically are performed on colonies of billions of cells. By analysing gene expression data of different cells going from yeast to mammalian cell cultures, we demonstrate that cell cultures display a sort of 'ecology-in-a-plate' giving rise to a rich dynamics of gene expression that are independent from reproductive cycles, hence contradicting simple ergodic assumptions The aspecific character of the observed coordinated gene expression activity inhibits any simple mechanistic hypothesis and highlights the need to consider population effects in the interpretation of data coming from cell cultures.
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