期刊
JOURNAL OF VIROLOGY
卷 81, 期 12, 页码 6761-6764出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02726-06
关键词
-
类别
资金
- NCI NIH HHS [R01 CA091791, CA91791] Funding Source: Medline
- NIDCR NIH HHS [R01 DE014153, R01 DE015752, DE14153, DE15752] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA091791] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE014153, R01DE015752] Funding Source: NIH RePORTER
Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown to be defective in late gene expression. Expression of early genes, as well as viral genome replication, was not affected. Furthermore, the defect in late gene expression was likely due to a deficiency in transcription. Thus, we have identified an MHV-68 protein, ORF24, that is essential for the expression of viral late proteins yet dispensable for viral DNA replication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据