期刊
NEUROSCIENCE RESEARCH
卷 57, 期 3, 页码 473-476出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2006.11.012
关键词
Parkinson's disease; CARD15; NOD2; genetic polymorphism
Recent reports have proven the importance of genetic factors and inflammation in the pathogenesis of sporadic Parkinson's disease (PD). In the current study, the frequency of CARD15/NOD2 gene variants (R702W, G908R, L1007fs), previously associated with Crohn's disease-a common inflammatory bowel disease, have been examined in a group of 308 sporadic PD patients and 220 healthy controls. Significantly higher frequency of total CARD15 variant alleles in PD patients (13.0%) compared to the controls (8.0%, p < 0.02) was observed. 24.0% of PD patients carried at least one CARD15 variant allele compared to 15.5% of healthy controls (p < 0.02, OR = 1.73). The results of the study suggest, that the polymorphism in CARD15/NOD2 gene may be a risk factor for sporadic PD development, and support the concept of inflammatory pathogenesis of PD. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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