期刊
ORGANIC LETTERS
卷 9, 期 5, 页码 943-945出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol070209i
关键词
-
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008194] Funding Source: NIH RePORTER
- NIGMS NIH HHS [S06 GM08194] Funding Source: Medline
The first organocatalytic highly enantioselective nitroaldol reaction of alpha-ketophosphonates and nitromethane has been realized by using cupreine (2) or 9-O-benzylcupreine (3) as the catalyst. Both catalysts are highly reactive and highly enantioselective. alpha-Hydroxy-beta-nitrophosphonates have been synthesized in good yields and excellent enantioselectivities (>= 90% ee) at a low catalyst loading (5 mol %). These nitroaldol products may be reduced to the biologically significant beta-amino-alpha-hydroxyphosphonates with complete retention of the stereochemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据