期刊
CANCER
卷 119, 期 24, 页码 4277-4283出版社
WILEY
DOI: 10.1002/cncr.28367
关键词
telomere length; peripheral blood leukocytes; oral premalignant lesion; oral squamous cell carcinoma; smoking; alcohol drinking
类别
资金
- National Cancer Institute (Specialized Center of Research Excellence [SPORE]) [P50 CA097007]
- MD Anderson Cancer Center Research Trust
- MD Anderson Cancer Center Start-Up Fund
BACKGROUND: Oral premalignant lesions (OPLs) are precursors of oral squamous cell carcinoma (OSCC). Short telomeres in peripheral blood leukocytes (PBLs) are associated with increased risks of several cancers. However, it is unclear whether short leukocyte telomere length (LTL) predisposes individuals to OPL and OSCC. METHODSLTL was measured in PBLs from 266 patients who had a diagnosis of either OPL (N=174) or OSCC (N=92) and from 394 age-matched and sex-matched controls. The association between LTL and the risk of OPL or OSCC, as well as the interaction of telomere length, cigarette smoking, and alcohol drinking on the risk of OPL or OSCC, were analyzed. RESULTSThe age-adjusted relative LTL was shortest in the OSCC group (1.640.29), intermediate in the OPL group (1.750.43), and longest in the control group (1.82 +/- 0.36; P-trend<.001). When the analysis was dichotomized at the median value in controls, adjusting for age, sex, smoking status, and alcohol drinking status, the odds ratio for the risk of OPL and OSCC associated with short LTL was 2.03 (95% confidence interval, 1.29-3.21) and 3.47 (95% CI, 1.84-6.53), respectively, with significant dose-response effects for both associations. Among 174 patients with OPL, 23 progressed to OSCC, and the mean LTL was shorter in progressors than in nonprogressors (mean +/- standard deviation: 1.66 +/- 0.35 vs 1.77 +/- 0.44, respectively), although the difference did not reach statistical significance (P=.258), probably because of the small number of progressors. An interaction analysis identified short LTL, smoking, and drinking alcohol as independent risk factors for OPL and OSCC. CONCLUSIONSShort LTL was associated with increased risks of developing OPL and OSCC. The current results also indicated that short LTL likely predisposes patients to the malignant progression of OPL. Cancer 2013;119:4277-4283. (c) 2013 American Cancer Society.
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