Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

Novel cationic liposomes, termed archaeosomes, based on mixtures of neutral/cationic bilayer-forming lipids and archaeobacterial synthetic tetraether-type bipolar lipids show efficient in vitro gene transfection properties and represent a new approach for modulating the lipidic membrane fluidity of the complexes they form with DNA.