期刊
CANCER
卷 118, 期 6, 页码 1574-1584出版社
WILEY
DOI: 10.1002/cncr.26447
关键词
multiple myeloma; head; intracranial; central nervous system; bortezomib; lenalidomide; thalidomide
类别
资金
- Celgene
BACKGROUND: Intracranial involvement in multiple myeloma is extremely rare. The effect of new drugs (eg, thalidomide, bortezomib, lenalidomide) with respect to old drugs (eg, alkylators, steroids) has not been reported. METHODS: We collected clinical and biological data of patients presenting with an osteo-dural or primary dural multiple myeloma (OD-DMM) or a central nervous system myelomatosis (CNS-MM) by sending a questionnaire to the centers of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA). RESULTS: A total of 50 patients were registered. New therapies were used in 35 patients, whereas 15 patients received old treatments. Twenty-five out of 50 patients obtained a complete remission or a very good partial remission (CR_VGPR). Overall survival (OS) for CNS-MM was 6 months, for OD-DMM 25 months. OS was 25 months for patients treated with new agents versus 8 months with old agents. Improved OS and progression-free survival were predicted by response (CR_VGPR) and by patients who underwent stem cell transplantation versus chemotherapy. b2-Microglobulin > 5 mmol/ L was a poor prognostic factor. Multivariate analysis showed poor survival for patients with b2-microglobulin > 5 mmol/ L and better survival for patients achieving CR_VGPR. CONCLUSIONS: The overall data highlight the relevance of therapy with new drugs in intracranial myeloma, providing a framework for future clinical trials. Cancer 2012; 118: 1574-84. VC 2011 American Cancer Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据