期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 5, 页码 1386-1391出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.11.081
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This Letter describes, for the first time, the synthesis and SAR, developed through an iterative analog library approach, that led to the discovery of the positive allosteric modulator (PAM) of the metabotropic glutamate receptor rnGluR5 CPPHA. Binding to a unique allosteric binding site distinct from other mGluR5 PAMs, CPPHA has been the focus of numerous pharmacology studies by several laboratories. (c) 2006 Elsevier Ltd. All rights reserved.
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