期刊
CANCER
卷 116, 期 10, 页码 2476-2485出版社
JOHN WILEY & SONS INC
DOI: 10.1002/cncr.24998
关键词
proton therapy; carbon-ion therapy; nonsmall cell lung cancer; stage I; hypofractionated high-dose irradiation
类别
资金
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
BACKGROUND: A study was undertaken to evaluate the clinical outcome of particle therapy for stage I nonsmall cell lung cancer (NSCLC) METHODS: From April 2003 to April 2007, 80 patients with stage I NSCLC were treated with proton therapy or carbon-ion therapy (57 with proton therapy and 23 with carbon-ion therapy) using 3 treatment protocols In the first protocol, 80 gray equivalents (GyE) of proton therapy was given in 20 fractions, and the second proton therapy protocol used 60 GyE in 10 fractions For carbon-ion therapy, 52 8 GyE was given in 4 fractions After achieving promising preliminary results for the first protocol, the authors started to use the second proton therapy protocol to shorten the overall treatment time Carbon-ion therapy was started in 2005, and thereafter, both proton and carbon-ion therapy plans were made for each patient, and the 1 that appeared superior was adopted Patient age ranged from 48 to 89 years (median, 76 years) Thirty-seven patients were medically inoperable. and 43 refused surgery Forty-two patients had T1 tumors, and 38 had T2 tumors RESULTS: The median follow-up period for living patients was 35 5 months For all 80 patients, the 3-year overall survival, cause-specific survival, and local control rates were 75% (1A 74%, 1B 76%), 86% (1A 84%, 1B 88%), and 82% (1A 87%, 1B 77%), respectively There were no significant differences in treatment results among the 3 protocols Grade 3 pulmonary toxicity was observed in only 1 patient CONCLUSIONS: Proton therapy and carbon-ion therapy are safe and effective for stage I NSCLC Further investigation of particle therapy for stage I NSCLC is warranted Cancer 2010;116:2476-85. (C) 2010 American Cancer Society
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