期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 1, 页码 278-281出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.07.088
关键词
cyclin-dependent kinases (CDKs) inhibitor; antiproliferative activity; flavonoids; apoptosis
A novel series of nitrogen-containing flavonoids 5a-1, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors. The representative compounds 5a, 5b, 5e, and 5g showed potent CDK1/Cyclin B inhibitory activities. All compounds displayed a significant growth inhibitory action in vitro against Bel-7402, PC-3, ECA-109, A-549, HL-60, and MCF-7 cancer cell lines. Flow cytometry analysis showed that 5b induced apoptosis in PC-3 cells. (c) 2006 Published by Elsevier Ltd.
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