期刊
JOURNAL OF HEPATOLOGY
卷 46, 期 1, 页码 45-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2006.08.021
关键词
interferon; chronic hepatitis B; hepatocellular carcinoma; cirrhosis; HBeAg seroconversion
Background/Aims: The long-term outcomes of interferon-alpha (IFN-alpha) therapy in hepatitis B e antigen (HBeAg) seropositive patients remain controversial. This study was conducted to address this issue. Methods: The long-term outcomes were compared in 233 IFN-treated patients and 233 well-matched untreated controls. Results: The cumulative incidence at the end of 15 years of follow-up (median 6.8 years, range 1.1-16.5 years) in the IFN-treated patients and controls was: HBeAg seroconversion 74.6% vs. 51.7% (P = 0.031); hepatitis B surface antigen (HBsAg) seroclearance 3% vs. 0.4% (P = 0.03); cirrhosis 17.8% vs. 33.7% (P = 0.041); and hepatocellular carcinoma (HCC) 2.7% vs. 12.5% (P = 0.011). Significant reduction of HCC was only observed in patients with pre-existing cirrhosis (P < 0.01). Compared with untreated controls with persistent HBeAg, HBeAg seroconverters in untreated and IFN-treated group showed significantly lower incidence of cirrhosis and HCC (P = 0.003-0.031), while non-seroconverters of IFN-treated group had marginally significant lower incidence of cirrhosis (P = 0.065). Multivariate analysis showed that IFN therapy, HBeAg seroconversion and genotype B HBV infection are independent factors for better long-term outcomes. Conclusions: IFN therapy reduces cirrhosis and HCC development. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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