期刊
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
卷 373, 期 -, 页码 521-532出版社
ELSEVIER
DOI: 10.1016/j.physa.2006.05.028
关键词
cellular Potts model; cell adhesion; chick limb growth; apical ectodermal ridge; fibroblast growth factor; CompuCell3D
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076692] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM076692, R01 GM076692-01] Funding Source: Medline
A central question in developmental biology is how cells interact to organize into tissues? In this paper, we study the role of mesenchyme-ectoderm interaction in the growing chick limb bud using Glazier and Graner's cellular Potts model, a grid-based stochastic framework designed to simulate cell interactions and movement. We simulate cellular mechanisms including cell adhesion, growth, and division and diffusion of morphogens, to show that differential adhesion between the cells, diffusion of growth factors through the extracellular matrix, and the elastic properties of the apical ectodermal ridge together can produce the proper shape of the limb bud. (c) 2006 Elsevier B.V. All rights reserved.
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