期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 92, 期 9, 页码 3660-3666出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2007-0790
关键词
-
资金
- NATIONAL CANCER INSTITUTE [R37CA054281, R25CA112355, R01CA063464, R01CA054281, U01CA063464] Funding Source: NIH RePORTER
- NCI NIH HHS [R25T CA 112355-01A1, CA 63464, CA 54281] Funding Source: Medline
Context: Both circulating levels and genetic variation of IGFs have been associated with cancer risk, yet the relationship between the two is not well understood. Objective: To investigate whether common genetic variation in IGF1, IGF binding protein 1 (IGFBP1), and IGFBP3 influences circulating levels of IGF-I, IGFBP-1, and IGFBP-3, we conducted a cross-sectional study of African-American, Native Hawaiian, Japanese-American, Latino, and white men and women in the Multiethnic Cohort. Design: Plasma levels of IGF-I, IGFBP- 1, and IGBFP-3 were measured by ELISA in a random sample of 837 Multiethnic Cohort participants. Previously identified tag single nucleotide polymorphisms ( SNPs) for IGF1 (29 tag SNPs) and IGFBP1/ IGFBP3 ( 23 tag SNPs) were genotyped among the 837 participants. Analysis of covariance was conducted to test for differences in mean IGF-I, IGFBP- 1, and IGFBP- 3 levels across respective IGF1, IGFBP1, and IGFBP3 genotypes, adjusting for previously identified dietary and lifestyle correlates. Results: Five highly correlated IGFBP3 SNPs (rs3110697, rs2854747, rs2854746, rs2854744, and rs2132570) demonstrated strongly significant associations with IGFBP- 3 levels when conservatively adjusted for multiple hypothesis testing (Bonferroni adjusted P trends = 7.75 X 10(-8) to 1.44 X 10(-5)). Patterns of associations were consistent across the five racial/ethnic groups. Conclusion: In summary, our study suggests that common genetic variation in IGFBP3 influences circulating levels of IGFBP- 3 among African-Americans, Native Hawaiians, Japanese-Americans, Latinos, and whites.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据