期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 45, 期 9, 页码 3008-3014出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02573-06
关键词
-
类别
In Europe, hemorrhagic fever with renal syndrome results mainly from infection with Puumala virus (PUUV) or Dobrava virus. For 31 patients from a hantavirus disease outbreak in Lower Bavaria, a district in southeast Germany, serodiagnosis was undertaken by enzyme-linked immuiniosorbent assay, immunofluorescence assay, and inummoblot analysis. In a few of these cases, however, PUUV-specific typing of antibodies by these standard assays failed and a virus neutralization assay under biosafet, level 3 conditions was required to verify the infection by this virus type. PUUV RNA was amplified by reverse transcription-PCR from acute-phase sera of three patients and was found to be very closely related to virus sequences obtained from bank voles (Clethrionomys glareolus) trapped in the same area. These findings link the outbreak with a novel PULTV lineage, Bavaria, circulating in the local rodent population. The Bavaria lineage associated with the outbreak is only distantly related to other PULTV lineages from Germany.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据