期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 42, 期 4, 页码 722-726出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.yjmcc.2007.02.002
关键词
translation research; cardiac myocyte; cardiac hypertrophy; sarcomeric proteins
资金
- NHLBI NIH HHS [P01 HL062426, HL62426, T32HL67548, R01 HL077195, F32 HL067548, HL077195] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL062426, R01HL077195, F32HL067548] Funding Source: NIH RePORTER
There has been increasing enthusiasm for biomedical research that focuses directly on human pathophysiology, in part fueled by the recent NIH roadmap initiative. While this approach has considerable merit, a myopic and primary focus on human disease and on human tissue introduces a plethora of research risks and concerns that could potentially complicate data interpretation and retard scientific progress. While some of these issues are generic when one extrapolates from animal models to the human circumstance, others are more specific to the cardiovascular system in general and to the study of cardiocyte biology in particular. This brief review will highlight some of these. (c) 2007 Elsevier Inc. All rights reserved.
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