期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 92, 期 3, 页码 787-796出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2006-2012
关键词
-
资金
- NCRR NIH HHS [RR-000055] Funding Source: Medline
- PHS HHS [U54-041859] Funding Source: Medline
Context: Polycystic ovary syndrome (PCOS) appears to arise as a complex trait with contributions from both heritable and nonheritable factors. Polygenic influences appear to account for about 70% of the variance in pathogenesis. In view of this evidence for congenital contributions to the syndrome, childhood manifestations may be expected. Objective: The objective has been to review the evidence that risk factors for PCOS can be recognized in childhood. Design: This study consisted of screening of the PCOS literature for articles pertaining to potential childhood and adolescent antecedents. Results: Congenital virilizing disorders; above average or low birth weight for gestational age; premature adrenarche, particularly exaggerated adrenarche; atypical sexual precocity; or intractable obesity with acanthosis nigricans, metabolic syndrome, and pseudo-Cushing syndrome or pseudo-acromegaly in early childhood have been identified as independent prepubertal risk factors for the development of PCOS. During adolescence, PCOS may masquerade as physiological adolescent anovulation. Asymptomatic adolescents with a polycystic ovary occasionally (8%) have subclinical PCOS but often (42%) have a subclinical PCOS type of ovarian dysfunction, the prognosis for which is unclear. Conclusion: Identifying children at risk for PCOS offers the prospect of eventually preventing some of the long-term complications associated with this syndrome once our understanding of the basis of the disorder improves.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据