期刊
PARKINSONISM & RELATED DISORDERS
卷 13, 期 5, 页码 290-294出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2006.11.011
关键词
Parkinson's disease; deep brain stimulation; subthalamic nucleus; verbal fluency; cerebral blood flow
We prospectively evaluated 20 patients with Parkinson's disease (PD) preoperatively and 12 months after subthalamic nucleus-deep brain stimulation (STN-DBS). All patients had clinical (UPDRS III) and neuropsychological evaluations as well as brain perfusion SPECT-ECD. Clinical and cognitive data were compared with 12 matched PD patients who had not undergone surgery. STN-DBS patients improved in motor symptoms and reduced medications but selectively declined in category fluency (P < 0.01). No clinical and cognitive changes were found in the control group at follow-up. Worsening fluency was associated with perfusion decrements in left dorsolateral prefrontal cortex, anterior cingulate cortex and ventral caudate nucleus (p <.001). (c) 2007 Elsevier Ltd. All rights reserved.
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