Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H-2-D2O system

A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D2O as a deuterium source under hydrogen atmosphere is described. Multideuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C-H-2-D2O system. ne present method does not require expensive deuterium gas or any special equipment.