期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 387, 期 2, 页码 371-380出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-006-0720-y
关键词
clinical/biomedical analysis; cell systems/single cell analysis; biosensors; biofilm; quorum sensing
资金
- NIDCD NIH HHS [R01 DC004173, R01 DC041734-04] Funding Source: Medline
As researchers attempt to study quorum sensing in relevant clinical or environmental settings, it is apparent that many factors have the potential to affect signaling. These factors span a range of physical, chemical, and biological variables that can impact signal production, stability and distribution. Optimizing experimental systems to natural or clinical environments may be crucial for defining when and where quorum sensing occurs. These points are illustrated in our case study of S. aureus signaling in biofilms, where signal stability may be affected by the host environment. The basic signaling schemes have been worked out at the molecular level for a few of the major quorum-sensing systems. As these studies continue to refine our understanding of these mechanisms, an emerging challenge is to identify if and when the local environment can affect signaling.
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