期刊
CANCER
卷 112, 期 6, 页码 1313-1324出版社
JOHN WILEY & SONS INC
DOI: 10.1002/cncr.23314
关键词
apolipoprotein A1; proApolipoprotein; central nervous system; metastatic brain cancer; cerebrovascular disease; lung cancer
类别
资金
- NHLBI NIH HHS [R01 HL051614, 2R01 HL51614] Funding Source: Medline
- NINDS NIH HHS [R01 NS43284, R01 NS049514-03, R01 NS38195, R21 NS077236, R01 NS049514, R01 NS038195] Funding Source: Medline
Background. Central nervous system (CNS) diagnostics is a promising tool for detection of neurological disorders, including brain metastases. One of the earliest applications of CNS diagnostics was based on serum markers of blood-brain barrier (BBB) dysfunction, which often correlates with acute, chronic, or incipient brain disease. In the case of brain metastases, serum levels of s100 beta demonstrated a good negative predictive value comparable to radiologic investigations. However, a confounding factor was the presence of BBB changes due to cerebrovascular disease. Methods. Of 103 patients enrolled in a lung cancer study, greater than 50% presented with magnetic resonance imaging (MRI) changes consistent with chronic cerebrovascular disease and reflected by elevated serum S100 beta. To unveil serum protein, the authors used proteomic techniques that allow discrimination between patients with brain metastases and lung cancer patients affected by cerebrovascular ischemic changes without infiltrating tumor. RESULTS. ProApolipo-protein A1, transferrin, haptoglobin, and transthyretin were upregulated in patients affected by chronic cerebrovascular disease and brain metastases compared with those affected only by vascular diseases. ProApolipo-protein A1 was significantly increased (p < .05) in patients with CNS disease. CONCLUSIONS. In conclusion, these data support the use of serum markers for the early detection of brain metastases. ProApolipo-protein A1 may be used in conjunction with S100 beta for serum-based, MRI-independent diagnosis of metastatic brain tumors.
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