期刊
CANCER
卷 112, 期 6, 页码 1264-1271出版社
WILEY
DOI: 10.1002/cncr.23310
关键词
cervical cancer; survival; race; socioeconomic status; surveillance; epidemiology; and end results
类别
资金
- NCI NIH HHS [P30 CA022453, T32 CA083654] Funding Source: Medline
BACKGROUND. African-American (AA) women have lower survival rates from cervical cancer compared with white women. The objective of this study was to examine the influence of socioeconomic status (SES) and other variables on racial disparities in overall survival among women with invasive cervical cancer. METHODS. One thousand thirty-six women (705 white women and 331 AA women) who were diagnosed with primary invasive cancer of the cervix between 1988 and 1992 were identified through the Metropolitan Detroit Cancer Surveillance System (MDCSS), a registry in the Surveillance, Epidemiology, and End Results (SEER) database. Pathology, treatment, and survival data were obtained through SEER. SES was categorized by using occupation, poverty, and educational status at the census tract level. Cox proportional hazards models were used to compare overall survival between AA women and white women adjusting for sociodemographics, clinical presentation, and treatment. RESULTS. AA women were more likely to present at an older age (P <.001), with later stage disease (P <.001), and with squamous histology (P =.01), and they were more likely to reside in a census tract categorized as Working Poor (WP) (P <.001). After multivariate adjustment, race no longer had a significant impact on survival. Women who resided in a WP census tract had a higher risk of death than women from a Professional census tract (P =.05). There was a significant interaction between disease stage and time with the effect of stage on survival attenuated after 6 years. CONCLUSIONS. In this study, factors that affected access to medical care appeared to have a more important influence than race on the long-term survival of women with invasive cervical cancer.
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