期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 13, 期 14, 页码 4094-4102出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200601684
关键词
allylic substitution; chirality; copper; dynamic processes; heterogeneous catalysis; racemization
Copper-catalyzed alpha-substitution of enantiomerically pure secondary allylic esters with Grignard reagents was studied with the aim to find conditions that give racemic products. it was observed that the degree of chiral transfer is strongly dependent on the temperature. The loss of chiral information is consistent with an equilibration of the Cu-III(allyl) intermediates prior to product formation. Equilibration of the reaction intermediates is of importance for a possible development of a dynamic kinetic asymmetric transformation (DYKAT) process, in which a chiral catalyst is used to produce an optically active product from a racemic substrate, by means of a dynamic equilibrium of the diastereomeric reaction intermediates.
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