期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 13, 期 5, 页码 1374-1381出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200601514
关键词
anion receptors; hydrogen bonds; molecular recognition; pyrroles; sensors
资金
- NIGMS NIH HHS [GM 58907] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM058907] Funding Source: NIH RePORTER
New cationic anion receptors, based on the use of pyrrole-substituted bipyridine and coordinated to transition metals, are described. Specifically, polypyridine-ruthenium and -rhodium cores have been functionalized to generate an anion binding site. The design was chosen to probe the influence of the pyrrole-to-pyrrole separation on anion-binding affinities and selectivities; this distance is greater in the new systems of this report (receptors I and 2) relative to that present in related dipyrrolyl quinoxaline based receptors 3 and 4. Solution-phase anion-binding studies, carried out by means of H-1 NMR spectroscopic titrations in [D-6]DMSO and isothermal titration calorimetry (ITC) in DMSO, reveal that I and 2 bind most simple anions with substantially higher affinity than either 3 or 4. In the case of chloride anion, structural studies, carried out by means of single-crystal X-ray diffraction analyses, are consistent with the solution-phase results and reveal that receptors I and 2 are both able to stabilize complexes with this halide anion in the solid state.
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