期刊
PARKINSONISM & RELATED DISORDERS
卷 13, 期 5, 页码 308-311出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2006.06.009
关键词
Parkinson's disease; orthostatic hypotension; insular cortex; neuropathology; post-mortem; Lewy bodies
资金
- NIMH NIH HHS [R03 MH074059-02, R03 MH074059] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH074059] Funding Source: NIH RePORTER
Orthostatic hypotension (OH) in Parkinson's disease (PD) patients may be a significant source of morbidity and discomfort. Although peripheral ANS components have been associated with its development, central mechanisms are probably involved. The insular cortex is a central site of autonomic and limbic integration and neuropathologic studies have indicated its involvement in the neurodegenerative process of PD. To this end, we studied the neuropathology of the insular, temporal and parietal cortices in PD patients with and without OR Our results suggest an association between the severity of PD-related neuropathology in the insular cortex and OH. Further research into the subject is warranted. (c) 2006 Elsevier Ltd. All rights reserved.
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